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Kidney toxicity of 3‐methylxanthine in the rat
Author(s) -
Sellman R.,
Klemi P. J.
Publication year - 1984
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550040605
Subject(s) - theophylline , creatinine , kidney , toxicity , metabolite , medicine , oral administration , acute tubular necrosis , blood urea nitrogen , pharmacology , endocrinology , urea , renal function , chemistry , organic chemistry
Abstract The effects of 3‐methylxanthine, the pharmacologically active metabolite of theophylline, on the kidneys of Wistar rats after short‐term administration were studied. 3‐Methylxanthine was administered in oral doses of 0 (control), 50, 100 and 200 mg per kg per day for 1, 8 and 16 days. The kidneys were examined by light and electron microscopy. Tubular necrosis was noticed at a dose level of 100 mg kg −1 after 16 days and at a dose level of 200 mg kg −1 after 8 days. Elevated values of serum urea were found after 1 day of treatment with a dose of 200 mg kg −1 and after 16 days with a dose of 100 mg kg −1 . Elevated values of serum creatinine were detected after 8 days of treatment with a dose of 200 mg kg −1 . The results indicate dose‐ and time‐related renal failure following administration of 3‐methylxanthine.