Premium
Lack of synergistic effect between arsenic, mercury and ethyl methane sulfonate on the frequency of chromosomal aberrations in mice
Author(s) -
Poma K.,
KirschVolders M.,
Susanne C.,
Degraeve N.
Publication year - 1984
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550040603
Subject(s) - methane sulfonate , arsenic , arsenic trioxide , mercury (programming language) , chemistry , sulfonate , body weight , chloride , environmental chemistry , toxicology , biochemistry , biology , organic chemistry , endocrinology , sodium , gene , computer science , mutant , programming language
The influence of arsenic and mercury on the frequency of chromosome aberrations induced by ethylmethane sulfonate was studied in mice. No synergistic effects could be demonstrated in somatic and germ cells of mice given a combined treatment of arsenic trioxide solution (As 2 O 3 , 12 mg per kg body weight) or of mercuric chloride solution (HgCl 2 , 6 mg per kg body weight) with ethylmethane sulfonate (EMS, 200 mg per kg body weight).