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Correction factors for determining body exposure from forearm percutaneous absorption data
Author(s) -
Guy Richard H.,
Maibach Howard I.
Publication year - 1984
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550040106
Subject(s) - forearm , body surface area , penetration (warfare) , body position , medicine , percutaneous , body surface , biomedical engineering , surgery , mathematics , physical medicine and rehabilitation , geometry , operations research
Evaluation of toxic exposure via the skin is invariably based upon forearm percutaneous absorption data and an appropriate area multiplication factor. Published experimental data clearly show, however, substantial site variation in skin penetration such that the use of forearm data may produce an inaccurate prediction of total body exposure. Using literature results for cutaneous absorption as a function of anatomic position and accepted estimations of human body surface areas, correction factors for use with forearm penetration data have been evaluated. Calculations have been performed for an adult, a small child and a neonate. Examples of limited exposure to specific regions of the body have also been assessed relative to predictions based upon percutaneous absorption across forearm skin. It appears that the use of forearm skin penetration data alone underestimates body exposure by at least a factor of two.