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Blood‐flow distribution in the mouse
Author(s) -
Stott William T.,
Dryzga Mark D.,
Ramsey John C.
Publication year - 1983
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550030607
Subject(s) - blood flow , pentobarbital , kidney , distribution (mathematics) , renal blood flow , medicine , endocrinology , chemistry , biology , mathematical analysis , mathematics
Abstract Blood‐flow distribution was determined in pentobarbital‐anesthetized male B6C3F1 mice, using intracardially administered 141 Ce‐radiolabelled microspheres (10μm). The proportion of cardiac output and blood flow per g tissue was determined in 18 organs and tissues, including the nasal cavity, lobes of the liver, individual kidneys and sections of the intestinal tract. To provide comparative data, blood‐flow distribution was also determined in pentobarbital‐anaesthetized male Fischer 344 rats. In general, there was close agreement between the distribution of blood flow between these two rodent species. The bladder and large intestine of mice appear to receive more, while the testes receive less, of the cardiac output than in rats. Rat liver and kidney, however, appear to receive approximately twice the amount of blood on a weight basis as in the mouse.