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Carbon disulphide intrauterine sensitization
Author(s) -
Tabacova Sonia,
Nikiforov Bojidar,
Balabaeva Liudmila
Publication year - 1983
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550030502
Subject(s) - hexobarbital , pregnancy , fetus , gestation , teratology , sensitization , inhalation , toxicity , physiology , prenatal development , embryogenesis , medicine , endocrinology , embryo , andrology , biology , enzyme , biochemistry , immunology , genetics , anesthesia , microsome
This study was designed to evaluate the effect of carbon disulphide (CS 2 ) exposure during pregnancy in two subsequent generations. Albino rats (F 1 ), which had been prenatally exposed by maternal inhalation to teratogenic (200 and 100 mgm −3 ) and subteratogenic (10 and 0.03 mg m −3 ) concentrations of CS 2 , were reared until maturity and mated to produce an F 2 generation. During pregnancy the F 1 females were again subjected to CS 2 exposure at the same concentrations as the F 0 females throughout gestation. Pre‐and postnatal development of F 1 and F 2 generations, as well as the corresponding maternal effects, were studied. Embryonic lethality, weight, congenital malformations, indices of lipid and energy metabolism, DNA and some liver drug metabolizing enzymes in maternal and fetal tissues were studied at term. Postnatal viability, physical and behavioral development, and hexobarbital sleeping time of the progeny were evaluated. Comparisons of CS 2 effect on F 1 and F 2 generations were performed. A marked increase in CS 2 ‐induced teratogenicity was found in the F 2 generation, together with retarded development of MFO system and increased postnatal behavioral effects. The results point to intrauterine sensitization of progeny to CS 2 ‐This effect is discussed in the light of possible interference of the agent with the hormonal programming of intrauterine development.