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Influence of experimental hepatic impairment on the toxicokinetics and the anticholinesterase activity of carbaryl in the rat
Author(s) -
Falzon M.,
Fernandez Y.,
CambonGros C.,
Mitjavila S.
Publication year - 1983
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550030207
Subject(s) - carbaryl , cholinesterase , toxicokinetics , tranylcypromine , toxicity , pharmacology , chemistry , liver function , medicine , endocrinology , toxicology , biology , monoamine oxidase , pesticide , biochemistry , enzyme , agronomy
The blood kinetics of carbaryl were followed over 24h after oral administration of 14 C‐carbaryl at 20 mg kg (0.17 μCi mg −1 ) in control animals and in animals with an altered liver function (70% hepatectomy or tranylcypromine treatment). The variations in the primary toxicity of carbaryl were assessed by measuring the inhibition of the plasma and erythrocyte cholinesterases and by evaluation of the lethal doses. The 14 C radioactivity in the blood and, in parallel, cholinesterase inhibition were maintained at a higher level in animals with an altered hepatic function. A study of acute toxicity also showed a decrease of the LD 50 (91 mg kg −1 with tranylcypromine, 342 mg kg −1 in the hepatectomized group) in the treated animals, with respect to the controls (585 mg kg −1 ). In all cases, tranylcypromine had a greater effect on blood kinetics, cholinesterase inhibition and LD 50 than did 70% hepatectomy.