Premium
Subchronic feeding study in rats of immobilized lactase following in utero exposure
Author(s) -
Becci Peter J.,
Gephart Larry A.,
Re Thomas A.
Publication year - 1983
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550030205
Subject(s) - lactase , in utero , body weight , medicine , endocrinology , food consumption , physiology , biology , pregnancy , fetus , food science , lactose , genetics , agricultural economics , economics
The effect of subchronic feeding of immobilized lactase composite following in utero exposure was studied in Sprague‐Dawley rats. The dose levels of immobilized lactase composite that were used were 25, 100 and 400 mg per kg body weight per day. Reproduction performance, body weight gain and food consumption, organ weight, hematological and clinical chemical data, and ophthalmic, gross and histopathological examinations were used to study possible toxicological or pathological effects. No treatment‐related effects were observed in either male or female rats exposed to immobilized lactase composite at any dose level.