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Investigation of the interaction between Probon® and indomethacin in rats
Author(s) -
Sebestyén Gyula,
Gergely Vera,
Virág Sándor,
Mészáros Zoltán
Publication year - 1983
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550030103
Subject(s) - analgesic , pharmacology , toxicity , drug , drug interaction , combination therapy , indometacin , microsome , side effect (computer science) , drug metabolism , medicine , chemistry , enzyme , enzyme inhibitor , biochemistry , prostaglandin endoperoxide synthase , computer science , programming language
The toxic side‐effects and anti‐inflammatory activity of combination treatment of Sprague‐Dawley rats with indomethacin and Probon, a new type of analgesic, were investigated. Following four weeks of treatment with a combination of these two drugs, the characteristic gastrointestinal side‐effect of indomethacin was markedly reduced. Mortality resulting from administration of the drug combination was significantly lower than that resulting from indomethacin treatment alone. The reduced toxicity of indomethacin in combination with Probon is probably due to a change in metabolism produced by the hepatic microsomal enzyme inducer, Probon. The anti‐inflammatory effect was also investigated using a contact thermographic method following one, three or seven days pretreatment. The advantage of this combination is that, using a higher dose of indomethacin in combination with the minor analgesic, we could achieve a more reliable anti‐inflammatory effect together with a pain‐killing action.