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Fluoride absorption through the hamster cheek pouch: A pH‐dependent event
Author(s) -
Whitford G. M.,
Callan R. S.,
Wang H. S.
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020608
Subject(s) - cheek pouch , fluoride , hamster , absorption (acoustics) , chemistry , dentistry , biophysics , medicine , inorganic chemistry , materials science , biology , composite material
The fractional absorptions of fluoride, 3 H 2 O, 125 I and 14 C‐DMO from the hamster cheek pouch were determined as functions of solution pH. When the pH was ≥5, fluoride absorption rate was inversely related to pH. The absorption rates of the other substances were not influenced by pH. The fractional absorptions of fluoride and 3 H 2 O were independent of fluoride concentrations over the range 1–53 mM. The data indicate that the absorption of fluoride through this keratinized epithelium occurs mainly by the diffusion of non‐ionic HF.