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Non‐mutagenicity of 2‐Methyl‐2,3‐Epoxybutane and factors influencing the mutagenicity of 2,3‐Epoxybutane
Author(s) -
De Meester C.,
Mercier M.,
Poncelet F.
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020604
Subject(s) - epoxide , mutagen , chemistry , strain (injury) , derivative (finance) , organic chemistry , carcinogen , catalysis , biology , anatomy , financial economics , economics
The compound 2,3‐epoxybutane (2,3‐EB) is a direct mutagen for the base‐pair‐substitution‐sensitive strains TA 1530, TA 1535 and TA 100, in the absence and in the presence of metabolic activation by liver S9‐mix. Under the same experimental conditions, the 2‐methyl derivative of 2,3‐EB was not mutagenic, up to 10 mg per plate. The parent compound (2,3‐EB) was more active on strain TA 1530 in the presence of liver S9‐mix. This was observed at every epoxide concentration tested. The increase of mutagenicity depended on the S9 concentration, the mix composition and to a small extent on the method utilized.