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Co‐enzyme effects of inorganic mercury in the liver of a freshwater fish Channa punctatus
Author(s) -
Rana S. V. S.,
Sharma Rekha
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020602
Subject(s) - mercury (programming language) , alkaline phosphatase , maltase , enzyme , chemistry , biochemistry , lipase , in vivo , lactase , mercury poisoning , acid phosphatase , enzyme assay , biology , toxicity , organic chemistry , microbiology and biotechnology , computer science , programming language
Mercury is known to modify enzyme activity through oxidation of thiol groups and respective reverse reactions in vitro and in vivo . However, variations in the activity of carbohydrases, and the significance of this variation after mercury poisoning in different species, has not been established. In the present report, the effects of inorganic mercury on selected hepatic enzymes was studied in the freshwater fish Channa punctatus . Quantitative data clearly showed a dose–response relationship between the amount of mercury retained in the liver and inhibition of enzymes (i.e. alkaline phosphatase, glucose‐6‐phosphatase, amylase, maltase, lactase, lipase and dehydrogenases). Mechanisms and significance of their modification have also been discussed.