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Inhibition of human erythrocyte and plasma cholinesterases by methamidophos
Author(s) -
Robinson Casey P.,
Beiergrohslein Donald
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020410
Subject(s) - methamidophos , human plasma , chemistry , pharmacology , toxicology , biology , pesticide , chromatography , ecology
Methamidophos (O, S‐dimethyl phosphoramidothioate) inhibition of human erythrocyte and plasma cholinesterase was studied in vitro. The pseudo‐biomolecular rate constant of inhibition was 3.14 ± 0.22 × 10 3 M −1 min −1 for erythrocyte cholinesterase and 1.85 ± 0.01 × 10 3 M −1 min −1 for plasma cholinesterase. Thus methamidophos, although quite toxic to mammals, is a slow, rather non‐selective inhibitor of human cholinesterases, as was also observed previously in rats.