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Urinary excretion of 5‐hydroxyindolacetic acid in occupational exposure to polyvinyl chloride and polyurethane foams
Author(s) -
Korićanac Z.,
Stanković B.,
Milovanović J. L.,
Dugandžić M.,
Trpković D.
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020408
Subject(s) - polyurethane , polyvinyl chloride , urine , metabolite , excretion , chemistry , chloride , tryptophan , metabolism , chromatography , toxicology , biochemistry , organic chemistry , biology , amino acid
The effect of plastics as polyurethane foams and polyvinyl chloride on the metabolism of tryptophan was investigated by determining the concentration of 5‐hydroxyindolacetic acid (5‐HIAA) as its metabolic end product excreted in the urine. Investigation of persons occupationally exposed to polyurethane and polyvinyl chloride showed that these plastics inhibit the metabolism of tryptophan, causing increased excretion of its easily measurable metabolite 5‐HIAA. This fact points to the possibility of practical use of this laboratory test which, together with other biological parameters, could improve methods for early detection of occupational exposure to polyurethanes and polyvinyl chloride.