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Toxicity of alcide
Author(s) -
AbdelRahman Mohamed S.,
Gerges Sammy E.,
Alliger Howard
Publication year - 1982
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550020308
Subject(s) - toxicity , erythema , irritation , hemolysis , cornea , medicine , physiology , acute toxicity , sensitization , median lethal dose , chemistry , pharmacology , surgery , immunology , ophthalmology
Alcide is now used as a liquid sterilizer in an ultrasonic cleaner. It is excellent for herpes, fungus of the fingernail, warts and treatment of burn infection. The active ingredients (AI's) in this compound are sodium chlorite (ClO 2 − ) and lactic acid. Studies were conducted to determine the toxicity of Alcide in its liquid and gel forms. The oral lethal doses after 14 days (LD 50 ) in female and male rats were 340 and 292 mg kg −1 (AI), respectively. No mortality occurred during the acute dermal toxicity study. The ocular irritation study in rabbits indicated redness in the conjunctivae within 1 h which became normal after 24 h. The cornea and iris remained without changes during the observation period. The guinea pig sensitization study revealed the occurrence of reversible necrosis after 3 days. On day 11, healing began and was completed by day 15 after the intradermal injection. No significant changes were observed in red blood cell compartments, glutathione levels, hemolysis, methemoglobin and blood chemistry in rabbits treated daily with 0.5, 1.0 or 2.0 (gm kg −1 ) Alcide for 1 month using intact and abraded skin.