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Effects of kola‐nut extract administration on the liver, kidney, brain, testis and some serum constituents of the rat
Author(s) -
Ikegwuonu F. I.,
Aire T. A.,
Ogwuegbu S. O.
Publication year - 1981
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550010603
Subject(s) - kidney , endocrinology , medicine , nut , garcinia kola , oral administration , cholesterol , body weight , bilirubin , biology , traditional medicine , structural engineering , engineering
Kola‐nut extract induced a number of overt neurotoxicological signs in male albino rats. A decrease in the total body weight and an increase in the absolute weights of the liver, kidney, brain and testis were observed after 18 weeks oral administration of kola‐nut extract to the rats. Total protein, RNA and DNA of these organs were significantly depressed. The activity of β‐glucuronidase and β‐galactosidase was induced only in the kidney, brain and testis of treated animals. While the levels of serum phosphomonoesterases and total cholesterol were significantly enhanced due to kola‐nut intake, serum total and conjugated bilirubin levels were significantly decreased.