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Lead‐induced experimental lesions of the testis and their treatment
Author(s) -
Ghelberg Naum W.,
Bordas Emeric
Publication year - 1981
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.2550010509
Subject(s) - lead acetate , body weight , endocrinology , medicine , germinal epithelium , basal (medicine) , testicle , chemistry , intraperitoneal injection , toxicity , group a , spermatogenesis , insulin
Abstract Thirty‐six healthy albino rats were divided into three groups and the histologic structure of the testes was examined after treatment: group ‘C’–10 healthy control rats were untreated; group ‘Pb’ – eight rats received intraperitoneal injections of 8.5 mg per kg body weight lead acetate for 154 days (15 doses in all); group ‘PbA’ – eight rats intoxicated with lead, like group ‘Pb’ but which, during the last 21 days before killing, were treated with 5 ml per kg body weight per day of a 2% injectable solution of sodium aspartate. As compared with the controls, group ‘Pb’ showed alteration of the histopathologic pattern and reduction in the size of seminiferous tubules, basal membrane separation and a decrease in the cell content of the germinal layer, lesions of the spermatocytes and spermatids, and slight oedematous dissociation in the interstice. In 75% of the group ‘PbA’ animals, normal aspects similar to those of group ‘C’ were found.