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Nervous system effects of dissolved and nanoparticulate cadmium in rats in subacute exposure
Author(s) -
Horváth Edina,
Oszlánczi Gábor,
Máté Zsuzsanna,
Szabó Andrea,
Kozma Gábor,
Sápi András,
Kónya Zoltán,
Paulik Edit,
Nagymajtényi László,
Papp András
Publication year - 2011
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1664
Subject(s) - inhalation exposure , inhalation , nervous system , toxicity , cadmium , chemistry , physiology , toxicology , medicine , pharmacology , anesthesia , biology , organic chemistry , psychiatry
Cadmium, a toxic heavy metal with various applications in technology, can affect people both by environmental (foodborne) and occupational (inhalation) exposure and can cause nervous system damage. To model this, rats were subacutely treated either with CdCl 2 solution per os (3.0 mg kg −1 b.w.) or nanoparticulate CdO 2 (particle size ca 65 nm) by intratracheal instillation (0.04 mg kg −1 b.w.) alone or in sequential combination. Nervous system effects were observed at different levels of function (open field behavior, cortical electrical activity, nerve action potential) and some general toxicological indicators were also measured. Three weeks of oral plus one week of intratracheal exposure caused significant reduction of body weight gain and open field motility. Lengthening of latency of sensory evoked potentials, observed in all treated rats, was also the most significant in the group receiving oral plus intratracheal treatment. Conduction velocity of the tail nerve was likewise decreased in all treated groups. Several of the effects pointed to a potentiating interaction between the two forms of Cd. Modeling environmental and occupational Cd exposure by oral and intratracheal application in rats was feasible, with results suggesting serious negative health effects in humans suffering such a combined exposure.