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Effect of leukotriene receptor antagonists on lung fibrosis in rats
Author(s) -
Shaker Olfat G.,
Sourour Doaa A.
Publication year - 2011
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1625
Subject(s) - montelukast , bleomycin , hydroxyproline , prednisone , pulmonary fibrosis , fibrosis , medicine , endocrinology , lung , myofibroblast , leukotriene , pharmacology , chemistry , chemotherapy , asthma
To compare the effects of montelukast, prednisone and the combination of both drugs in a rat model of bleomycin‐induced lung fibrosis. Rats, injected intravenously with bleomycin daily for five consecutive days, were treated with either montelukast, prednisone or a combination of both drugs orally daily for 35 days starting 14 days after the commencement of the first dose of bleomycin. Montelukast‐treated rats showed reduction in collagen deposition by 29% and significant reduction in lung hydroxyproline content by 32%. Prednisone produced nonsignificant difference in collagen deposition and in lung hydroxyproline content compared with the bleomycin group. There was also a significant reduction in collagen deposition and hydroxyproline content in montelukast and prednisone treated rats by 15 and 17%, respectively, compared with bleomycin group. A significant reduction occurred in the mean area percentage of myofibroblast α smooth muscle actin in montelukast and montelukast and prednisone‐treated groups by 41 and 37%, respectively, with nonsignificant difference in prednisone‐treated rats as compared with the bleomycin group. Montelukast may be therapeutically effective for inhibiting further progression of lung fibrosis through inhibition of α ‐SMA positive myofibroblasts. Copyright © 2011 John Wiley & Sons, Ltd.