Premium
Nano‐CuO inhibited voltage‐gated sodium current of hippocampal CA1 neurons via reactive oxygen species but independent from G‐proteins pathway
Author(s) -
Liu Zhaowei,
Liu Shichang,
Ren Guogang,
Zhang Tao,
Yang Zhuo
Publication year - 2011
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1611
Subject(s) - reactive oxygen species , hippocampal formation , chemistry , nano , biophysics , sodium , oxygen , sodium channel , biochemistry , biology , materials science , neuroscience , organic chemistry , composite material
ABSTRACT The aim of this study was to investigate the effects of nano‐CuO on voltage‐gated sodium current ( I Na ) in hippocampal CA1 neurons. The results suggested that nano‐CuO inhibited amplitudes of I Na currents and prolonged peak rise time of action potential (AP). The responses to nano‐CuO were inhibited by reactive oxygen species (ROS) scavenger. However, the G‐proteins inhibitor did not block the effects of nano‐CuO. The effects of nano‐CuO were mediated through activation of ROS‐ I Na ‐AP signaling cascades and independent from G‐proteins pathway. Copyright © 2011 John Wiley & Sons, Ltd.