Thymocytes are activated by toluene inhalation through the transcription factors NF‐ κ B, STAT5 and NF‐AT | Zendy

Liu Jiqin | Zendy; Yoshida Yasuhiro | Zendy; Kunugita Naoki | Zendy; Noguchi Junko | Zendy; Sugiura Tsutomu | Zendy; Ding Ning | Zendy; Arashidani Keiichi | Zendy; Fujimaki Hidekazu | Zendy; Yamashita Uki | Zendy

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Thymocytes are activated by toluene inhalation through the transcription factors NF‐ κ B, STAT5 and NF‐AT

Author(s) -

Liu Jiqin,

Yoshida Yasuhiro,

Kunugita Naoki,

Noguchi Junko,

Sugiura Tsutomu,

Ding Ning,

Arashidani Keiichi,

Fujimaki Hidekazu,

Yamashita Uki

Publication year - 2010

Publication title -

journal of applied toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.784

H-Index - 87

eISSN - 1099-1263

pISSN - 0260-437X

DOI - 10.1002/jat.1536

Subject(s) - toluene , inhalation , immune system , nf κb , transcription factor , chemistry , stat5 , immunology , biology , microbiology and biotechnology , signal transduction , inflammation , biochemistry , anatomy , gene , organic chemistry

Toluene has been extensively examined for effects on the central nervous system. To investigate the influence of low‐level inhalation of toluene on the naive immune cells, male C3H/HeN mice were exposed to filtered air (control) and 50 ppm of toluene for 3 weeks. Low‐level exposure resulted in (1) increased proliferation of thymocytes, (2) IL‐2 production induced in thymocytes and (3) activation of the transcription factors NF‐ κ B, STAT5 and NF‐AT in thymocytes. These results suggest that thymocytes are sensitive cells and T cell activators are candidates for biomarkers for low‐level exposure to toluene on naive immune cells. Copyright © 2010 John Wiley & Sons, Ltd.

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