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In vivo growth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from the Piper species
Author(s) -
Bezerra Daniel P.,
Pessoa Cláudia,
Moraes Manoel Odorico de,
Alencar Nylane M. N. de,
Mesquita Rodney O.,
Lima Michael W.,
Alves Ana Paula N. N.,
Pessoa Otília Deusdênia L.,
Chaves João Henrique,
Silveira Edilberto R.,
CostaLotufo Letícia V.
Publication year - 2008
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1311
Subject(s) - in vivo , alkaloid , pharmacology , piper , in vitro , piperaceae , kidney , chemistry , sarcoma , traditional medicine , biology , medicine , biochemistry , pathology , microbiology and biotechnology , stereochemistry , endocrinology
Abstract Many authors have already emphasized that phytochemicals from spices have biological applications. Piperlonguminine is a known alkaloid amide from peppers, including Piper divaricatum. The aim of this study was to investigate the in vitro and in vivo antitumor effects of piperlonguminine in experimental models. In order to evaluate the toxicological aspects related to piperlonguminine treatment, hematological, biochemical, histopathological and morphological analyses of treated animals were performed. Piperlonguminine did not show any significant in vitro cytotoxic effect at experimental exposure levels, but showed an in vivo antitumor effect. After 7 days of treatment, the inhibition rates were 38.71% and 40.68% at doses of 25 mg kg −1 and 50 mg kg −1 , respectively. The histopathological analysis suggests that the liver and kidney were only weakly affected by piperlonguminine treatment. Neither the enzymatic activity of transaminases (AST and ALT) nor the urea levels were significantly altered. In the hematological analysis, all parameters analysed remained constant after piperlonguminine treatment. In conclusion, these data reinforce the anticancer potential of spice components. Copyright © 2007 John Wiley & Sons, Ltd.