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Ebselen attenuates cadmium‐induced testicular damage in mice
Author(s) -
Ardais Ana P.,
Santos Francielli W.,
Nogueira Cristina W.
Publication year - 2008
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1282
Subject(s) - ebselen , lipid peroxidation , chemistry , ascorbic acid , antioxidant , oxidative stress , glutathione , pharmacology , glutathione peroxidase , thiol , biochemistry , intraperitoneal injection , endocrinology , medicine , enzyme , food science
This study was designed to examine if ebselen, an organoselenium compound with antioxidant and glutathione peroxidase‐mimetic properties, attenuates testicular injury caused by intraperitoneal administration of CdCl 2 . A number of toxicological parameters were evaluated in the testes of mice, such as δ‐ aminolevulinic acid dehydratase ( δ‐ ALA‐D) activity, lipid peroxidation, ascorbic acid levels and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Ebselen attenuated lipid peroxidation levels altered by CdCl 2 . δ‐ ALA‐D activity inhibited by the highest dose of CdCl 2 was attenuated by ebselen. A significant negative correlation between lipid peroxidation levels and δ‐ ALA‐D activity was observed. Ebselen restored ascorbic acid levels reduced by CdCl 2 . A significant negative correlation between ascorbic acid levels and δ‐ ALA‐D activity reinforces the idea that ebselen attenuated the damage induced by CdCl 2 via its antioxidant property. The significant correlation between ALT and δ‐ ALA‐D activity supports the assumption that ebselen prevented damage caused by CdCl 2 . The results show that ebselen attenuated oxidative stress, a process important for CdCl 2 toxicity. Copyright © 2007 John Wiley & Sons, Ltd.