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The organophosphate‐induced acute‐phase response is characterized by synthesis of α 1 ‐acid glycoprotein that exhibits an immunomodulatory effect
Author(s) -
IvanovićMatić Svetlana,
Poznanović Goran,
Grigorov Ilijana,
Dinić Svetlana,
Mihailović Mirjana,
Grdović Nevena,
Uskoković Aleksandra,
Martinović Vesna,
Arambašić Jelena,
Petrović Miodrag,
Bogojević Desanka
Publication year - 2008
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1254
Subject(s) - paraoxon , organophosphate , chemistry , stimulation , in vivo , pharmacology , soman , turpentine , mechanism of action , in vitro , biochemistry , medicine , biology , acetylcholinesterase , enzyme , pesticide , microbiology and biotechnology , organic chemistry , agronomy
The organophosphorus compounds soman and paraoxon induce the acute‐phase (AP) response. All phases of the AP response, from macrophage activation and stimulation of glucocorticoid secretion to AP protein expression appear to be under the control of similar molecular mechanisms to those during the turpentine‐induced AP response. The AP protein content in the circulation 24 h after either soman, paraoxon or turpentine administration was injury‐specific. Both soman and paraoxon poisoning were characterized by significantly increased synthesis of α 1 ‐acid glycoprotein (AGP) that displayed an immunomodulatory effect in vitro . This result suggests that after organophosphate poisoning AGP participates in vivo in a negative feedback mechanism that prevents over‐activity of the immune system. Copyright © 2007 John Wiley & Sons, Ltd.