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Citrinin and endosulfan induced maternal toxicity in pregnant Wistar rats: pathomorphological study
Author(s) -
Singh Nittin D.,
Sharma Anil K.,
Dwivedi Prabhaker,
Patil Rajendra D.,
Kumar Manoj
Publication year - 2007
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1242
Subject(s) - toxicity , endosulfan , citrinin , pregnancy , physiology , reproductive toxicity , medicine , toxicology , andrology , chemistry , biology , pesticide , mycotoxin , food science , genetics , agronomy
Abstract Dietary exposures to environmental food pollutants such as mycotoxin(s) or pesticide(s) have gained immense significance due to their adverse effects on production and reproduction in animal and human populations. The present investigation was conducted to evaluate the maternal toxicity of citrinin (CIT) and endosulfan administered per os either alone or in combination in pregnant rats during gestational days 6–20. CIT (group I, 10 mg kg −1 feed, through diet) and endosulfan (group II, 1 mg kg −1 body weight, by oral intubation) when administered either alone or in combination (group III) in Wistar rats caused clinical signs of toxicity and pathomorphological changes in all the toxin treated groups, the severity being more pronounced in the combination treatment compared with that observed in the control (group IV). The rate of fetal resorptions was highest (22.22%) in the combination treatment followed by endosulfan (16.48%) and CIT (12.50%) treatment groups compared with the control group (3.86%). The histopathological changes such as engorged vasculature, vacuolar degeneration and karyomegaly in liver; congestion, tubular degeneration and cast formation in kidneys; vascular changes and hemosiderosis in uterus and lymphocytic depletion and apoptosis in the lymphoid organs were recorded in the animals of the toxin treated groups. The lesions were consistent and more severe in the combination treatment group compared with the individual treatment groups, suggesting an additive interaction of CIT and endosulfan in inducing maternal toxicity in Wistar rats. Copyright © 2007 John Wiley & Sons, Ltd.