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Genotoxicity study in lymphocytes of offset printing workers
Author(s) -
Aksoy Hüseyin,
Yõlmaz Serkan,
Çelik Mustafa,
Yüzbaşıoǧlu Deniz,
Ünal Fatma
Publication year - 2005
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1098
Subject(s) - sister chromatids , genotoxicity , micronucleus test , mitotic index , occupational exposure , offset printing , sister chromatid exchange , toxicology , micronucleus , medicine , genetics , biology , toxicity , chromosome , environmental health , mitosis , materials science , dna , composite material , gene , inkwell
The potential cytogenetic damage in offset printing workers was evaluated using sister chromatid exchanges (SCEs), chromosome aberrations (CAs) and micronuclei (MN) as biomarkers in peripheral lymphocytes of 26 volunteers (14 workers, 12 controls). The CA, SCE and MN frequency of offset printing workers was significantly higher than in their controls. The replication index (RI) was not affected while the mitotic index (MI) was affected most in the workers. It can be concluded from this study that chronic occupational exposure to printing dyes and thinner may lead to a slightly increased risk of genetic damage among offset printing workers. Copyright © 2005 John Wiley & Sons, Ltd.