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Effective bisquaternary reactivators of tabun‐inhibited AChE
Author(s) -
Kuca Kamil,
Cabal Jiri,
Musilek Kamil,
Jun Daniel,
Bajgar Jiri
Publication year - 2005
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1084
Subject(s) - tabun , chemistry , aché , pharmacology , acetylcholinesterase , medicine , biochemistry , enzyme
Two cholinesterase reactivators (K074 and K075) were synthesized and their reactivation efficacy against tabun‐inhibited acetylcholinesterase of the rat brain was tested in vitro . Comparing this efficacy showed that commonly used oximes (pralidoxim, obidoxime and HI‐6) were practically without reactivation potency. On the other hand, oximes K074, K075 and trimedoxime were satisfactorily effective. Moreover, K‐oximes reactivated tabun‐inhibited AChE at lower concentration (10 −4 and 10 −3 m ) in comparison with trimedoxime (10 −3 and 10 −2 m ). Thus, K‐oximes can be considered as the most effective reactivators of tabun‐inhibited AChE at present. Copyright © 2005 John Wiley & Sons, Ltd.