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In vitro reactivation potency of some acetylcholinesterase reactivators against sarin‐ and cyclosarin‐induced inhibitions
Author(s) -
Kuca Kamil,
Cabal Jiri,
Jun Daniel,
Kassa Jiri,
Bartosová Lucie,
Kunesová Gabriela
Publication year - 2005
Publication title -
journal of applied toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.784
H-Index - 87
eISSN - 1099-1263
pISSN - 0260-437X
DOI - 10.1002/jat.1065
Subject(s) - sarin , pralidoxime , chemistry , acetylcholinesterase , pharmacology , aché , enzyme , biochemistry , medicine
In our study, we have tested six acetylcholinesterase (AChE) reactivators (pralidoxime, obidoxime, HI‐6, trimedoxime, BI‐6 and Hlö‐7) for reactivation of sarin‐ and cyclosarin‐inhibited AChE using an in vitro reactivation test. We have used rat brain homogenate as the suitable source of enzyme. All oximes are able to reactivate sarin‐inhibited AChE. On the other hand, only HI‐6 is able to reactivate satisfactorily cyclosarin‐inhibited AChE. Copyright © 2005 John Wiley & Sons, Ltd.