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2018 ACCP Global Conference on Clinical Pharmacy: October 20–23, 2018
Author(s) -
Hua Ling,
David Ombengi,
Thuymy Nguyen
Publication year - 2018
Publication title -
journal of the american college of clinical pharmacy
Language(s) - English
Resource type - Journals
ISSN - 2574-9870
DOI - 10.1002/jac5.1059
Subject(s) - pharmacy , medicine , clinical pharmacy , family medicine , medical education
1. Trends of sources of adverse drug reactions reports in a spontaneous reporting system in Taiwan Yuk-Ying Chan, MS, Shih-Chieh Shao, MS; Department of Pharmacy, Linkou Chang Gung Memorial Hospital, Linkou, Taiwan School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan INTRODUCTION: Analyses of adverse drug reaction (ADR) reports were clinically relevant issues to avoid unintended outcomes of patients. Understanding the trends of sources of ADR reports could help us to develop a strategy to improve underreporting of ADR. RESEARCH QUESTION OR HYPOTHESIS: To investigate the trends of sources in a spontaneous ADR reporting system in Taiwan. STUDY DESIGN: Observational study. METHODS: We extracted the data from the spontaneous ADR reporting system of the Chang Gung Medical Foundation (CGMF), which consists of 2 medical centers, 2 regional hospitals and 3 district hospitals in Taiwan, from 2005-2014. We classified the sources by following categories: 1) level of hospitals: medical centers, regional hospitals and district hospitals 2) settings: inpatients, outpatients and emergent rooms, and 3) healthcare providers: clinicians, nurses and pharmacists. We calculated the proportions of each category and compared proportions in 2005 and 2014 with chi-square tests considering 2-sided P value <0.05 to be statistically significant for examining whether the changes existed over time. RESULTS: We identified a total of 19,056 ADR reports and the number of reports increased 14.84% during study period. Most of ADR reports were from inpatient (50.3%), medical centers (63.6%) and clinicians (66.7%). Between 2005 and 2014, we found the proportion of sources of ADR reports from medical centers and outpatients increased from 57.1% to 65.9% (p<0.01) and 46.6% to 51.9% (p=0.02), respectively; however, regional hospitals and inpatients accounted for decreased proportion of sources of ADR reports from 42.9% to 27.4% (p<0.01) and 48.8% to 44.2% (p=0.008), respectively. No significant changes of the proportion of ADR reports from different healthcare providers. CONCLUSION: We found the proportion of sources of ADR reports changed over time, especially for decreased proportion of regional hospitals and inpatients. It warranted further investigations to identify the factors affecting the reporting rate.