Open AccessHypoxic‐ischemic brain injury and narcotic drugs administration
Author(s) -
Xiong LiuLin,
Zhou HongSu,
Li TingTing,
Xiao QiuXia,
Zhu ZhaoQiong
Publication year - 2020
Publication title -
ibrain
Language(s) - English
Resource type - Journals
eISSN - 2769-2795
pISSN - 2313-1934
DOI - 10.1002/j.2769-2795.2020.tb00048.x
Subject(s) - ischemia , hypoxia (environmental) , pharmacology , medicine , narcotic , excitatory postsynaptic potential , narcotic analgesics , neurotoxicity , lipid peroxidation , neuroscience , neuroprotection , reperfusion injury , anesthesia , chemistry , cardiology , biology , toxicity , oxidative stress , oxygen , inhibitory postsynaptic potential , organic chemistry , morphine
Following cerebral ischemia and hypoxia, disorders in brain metabolism, histological pathology, and neural function commonly could result in different nerve injuries, to some degree. Many researchers have revealed that some narcotic drugs hold a prominent effect of prevention and therapy on cerebral ischemic‐hypoxic injury and ischemia‐reperfusion injury. However, the underlying mechanism is largely unknown. In this paper, we summarized narcotic drugs’ roles in antagonizing the neurotoxicity of excitatory amino acid, reducing excitatory injury and activating intracellular signaling cascade channel, adjusting the balance of Ca 2+ , increasing the expression of protective genes, reducing the generation of NO and free radical and anti‐lipid peroxidation, and discussed and elucidated their relations.