Open AccessRelationship between interleukin‐6 and brain ischemia
Author(s) -
Hu Yue,
Xu Yang
Publication year - 2019
Publication title -
ibrain
Language(s) - English
Resource type - Journals
eISSN - 2769-2795
pISSN - 2313-1934
DOI - 10.1002/j.2769-2795.2019.tb00039.x
Subject(s) - medicine , ischemia , inflammation , immune system , mechanism (biology) , brain edema , proinflammatory cytokine , stroke (engine) , immunology , central nervous system , brain ischemia , disease , interleukin , inflammatory response , neuroscience , cytokine , pathology , cardiology , biology , mechanical engineering , philosophy , epistemology , engineering
Ischemic stroke is the most common disease of nervous system associated with high mortality worldwide. After the primary injury, secondary injury is caused by activation of the immune response due to an influx of neuro‐inflammatory cells increasing the production of inflammatory cytokines and edema. Inflammatory factors, such as interleukin‐6 (IL‐6) , are suspected to play a role in arterial thrombogenesis. IL‐6 has a double role of pro‐inflammatory and anti‐inflammatory responding to the brain injury. Many of its effects are caused by trans‐signaling. However, the relationship between IL‐6 and brain ischemia remains unclear. Here we tried to review the role of IL‐6 in brain ischemia and summarized the underlying molecular mechanism.