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Stability of Amoxycillin, Clindamycin and Meropenem in Peritoneal Dialysis Solution
Author(s) -
Tran Minh D,
Sharley Nicholas,
Ward Michael
Publication year - 2012
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2012.tb00174.x
Subject(s) - meropenem , peritoneal dialysis , clindamycin , medicine , antibiotics , dialysis , microbiology and biotechnology , chromatography , chemistry , antibiotic resistance , biology
Aim To determine the stability of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution containing glucose 2.5% at 37 °C over 6 hours. Method A stability‐indicating high‐performance liquid chromatography assay was used to determine the concentration of amoxycillin, clindamycin and meropenem in peritoneal dialysis solution (Dianeal PD‐4). Antibiotic solutions (amoxycillin 1 g, clindamycin 300 mg, meropenem 1 g) were prepared in 2 L peritoneal dialysis bags and stored at 37 °C. These were analysed at 0, 3 and 6 hours. A degradation profile was constructed for each antibiotic using linear regression and concentration remaining at 6 hours was calculated. Results Clindamycin and meropenem retained at least 90% or greater of the original concentration in the peritoneal dialysis solution over 6 hours, while amoxycillin displayed marginal stability. Conclusion Clindamycin and meropenem are stable for 6 hours in peritoneal dialysis solution containing 2.5% glucose. Amoxycillin's stability was marginal, which could be improved with a modified formulation.