Premium
External Surface Contamination of Cytotoxic Admixtures: Caveat Emptor
Author(s) -
Siderov Jim,
Kirsa Sue,
McLauchlan Robert
Publication year - 2011
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2011.tb00856.x
Subject(s) - contamination , medicine , cytotoxic t cell , dry cleaning , waste management , toxicology , engineering , in vitro , chemistry , biology , ecology , biochemistry
Background Published studies suggest that cytotoxic contamination in the workplace may originate from the external surface of commercially available vials. No published studies were found describing the testing of surface contamination of cytotoxic products purchased from commercial compounders. Aim To determine if cytotoxic admixtures purchased from a commercial compounder would test positive for surface contamination with cyclophosphamide. Method Surface wipe sampling was performed to detect cyclophosphamide surface contamination on products sourced from a commercial compounder. Surface wipe sampling was performed using previously published methods. Results Surface contamination was detected on all of the samples taken. Conclusion Cytotoxic products purchased from commercial compounders may have external surface cytotoxic contamination. Safe handling procedures should be instituted for these products.