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Properties of a Formulated Paediatric Phenobarbitone Oral Liquid
Author(s) -
Garg Sanjay,
Svirskis Darren,
Myftiu Joana,
Behayaa Maryam,
Shahin Dina,
Thrimawithana Thilini,
Vidicki Adela,
Kairuz Therese
Publication year - 2008
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2008.tb00791.x
Subject(s) - palatability , medicine , viscosity , chromatography , taste , food science , chemistry , materials science , composite material , pathology
Aim To formulate a stable and palatable paediatric phenobarbitone 10 mg/mL oral liquid and compare its physicochemical stability to the existing formulation compounded in some New Zealand hospitals. Method Formulations were compounded from pharmaceutical standard ingredients according to good manufacturing practices and stored in glass bottles at different storage conditions. The physical stability of the formulations was determined by pH, appearance, viscosity and microbial studies; chemical stability was assessed using high performance liquid chromatography. Results The new formulation and the existing hospital formulation remained physically stable for 28 days in terms of pH, appearance, viscosity and microbial stability. The phenobarbitone sodium concentration remained within an acceptable range (above 95% of the original concentration) after 28 days of storage at different conditions. The viscosity of the new formulation facilitated in masking phenobarbitone sodium's bitter taste, thus improving palatability. The palatability of the new formulation was superior to the hospital formulation. Conclusion A palatable paediatric phenobarbitone oral liquid formulation with improved rheological properties was developed.