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Variation in Paediatric Omeprazole Dosing
Author(s) -
Graudins Linda V
Publication year - 2008
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2008.tb00390.x
Subject(s) - dosing , medicine , omeprazole , guideline , enteral administration , medical prescription , pediatrics , intensive care medicine , pharmacology , parenteral nutrition , pathology
Aim To characterise enteral omeprazole prescribing for paediatric inpatients; to compare doses prescribed for tablets and mixtures; and to compare doses prescribed to a nationally recognised paediatric dosing guideline. Method A cross‐sectional study conducted at a paediatric hospital where pharmacists prospectively collected dose and formulation data for all paediatric inpatients prescribed enteral omeprazole over a 2–week period. Result 35 children (8.6% inpatients) were prescribed enteral omeprazole. Omeprazole doses varied from 0.5 to 3.7 mg/kg/day (median 1.2), higher doses were prescribed for infants and for the mixture formulation. Less than half of the prescriptions followed the nationally recognised paediatric dosing guideline. Conclusion There was a wide variation in omeprazole dosing in children. Studies of the stability and bioavailability of omeprazole along with clinical outcomes are needed to establish optimal dosing, especially in younger children.