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Artemether‐Lumefantrine and Primaquine for Mixed Plasmodium falciparum and ovale Malaria
Author(s) -
Chan Esther W
Publication year - 2006
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2006.tb00589.x
Subject(s) - primaquine , artemether/lumefantrine , medicine , lumefantrine , malaria , artemether , quinine , regimen , plasmodium falciparum , plasmodium ovale , pharmacology , immunology , plasmodium vivax , artemisinin , chloroquine
Aim To present a case of uncomplicated mixed Plasmodium falciparum and ovale malaria requiring treatment with artemether‐lumefantrine and primaquine. Clinical features A 40‐year‐old female presented with a mixed infection of uncomplicated P. falciparum and ovale . Treatment was commenced with oral quinine sulphate 600 mg, 8‐hourly which was changed to artemether‐lumefantrine and primaquine. A glucose‐6‐phosphate‐dehydrogenase test revealed deficiency, necessitating an alteration of the primaquine regimen. Discussion Malaria infections are often initially treated with quinine if the infective species is not known or if the infection is mixed. Oral quinine remains useful in the treatment of uncomplicated P. falciparum malaria, however the six‐dose regimen of artemether‐lumefantrine is an effective alternative. Conclusion This case highlights the benefits of artemether‐lumefantrine for mixed‐uncomplicated malaria and the use of primaquine for eradication of liver stages for P. ovale infections.