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Thiopurines for Inflammatory Bowel Disease: Role of Pharmacogenetics
Author(s) -
Hadithy Asmar FY Al,
Naunton Mark,
Brouwers Jacobus RBJ
Publication year - 2005
Publication title -
journal of pharmacy practice and research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.222
H-Index - 22
eISSN - 2055-2335
pISSN - 1445-937X
DOI - 10.1002/j.2055-2335.2005.tb00343.x
Subject(s) - pharmacogenetics , thiopurine methyltransferase , medicine , inflammatory bowel disease , pharmacology , disease , genotype , genetics , gene , biology
There is a growing interest in the use of thiopurines for inflammatory bowel disease. Pharmacogenetic insights suggest that the genetic profile of thiopurine S‐methyltransferase and inosine triphosphate pyrophosphatase may affect the clinical response to thiopurines. This is a review on the pharmacogenetics of these enzymes and highlights difficulties that impede prior‐to ‐treat pharmacogenetic testing for the thiopurines in practice.