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Bioactive Oxylipins in Saccharomyces cerevisiae
Author(s) -
Strauss C.J.,
Kock J.L.F.,
Wyk P.W.J.,
Lodolo E.J.,
Pohl C.H.,
Botes P.J.
Publication year - 2005
Publication title -
journal of the institute of brewing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 51
eISSN - 2050-0416
pISSN - 0046-9750
DOI - 10.1002/j.2050-0416.2005.tb00688.x
Subject(s) - candida albicans , saccharomyces cerevisiae , yeast , oxylipin , fermentation , chemistry , aspirin , biofilm , corpus albicans , microbiology and biotechnology , biochemistry , biology , bacteria , gene , genetics
Some strains of Saccharomyces cerevisiae (including strains used in fermentation processes) produce short chain (mainly 8 carbon) oxylipins and not potent inflammatory long chain (20 carbon) oxylipins such as prostaglandins. When acetylsalicylic acid (aspirin) was added to cultures of Sacch. cerevisiae UOFS Y‐2330, flocculation was significantly inhibited as well as the production of 3‐hydroxy 8:0 thereby linking flocculation and this oxylipin. Furthermore, no traces of 3‐hydroxy 8:0 could be detected at the start of flocculation in this yeast. This research is based on (i) reports that yeasts in general can produce bioactive prostaglandins, (ii) findings suggesting a link between aspirin‐sensitive prostaglandins and biofilm formation by Candida albicans , (iii) the discovery that the addition of low concentrations of aspirin abolish yeast biofilm formation and sexual cell aggregation and (iv) the recent discovery of a novel potent aspirin‐sensitive pro‐inflammatory 3‐hydroxy prostaglandin E 2 synthesized by Candida albicans in conjunction with mammalian cells probably during candidiasis.