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HORDENINE AS THE PRECURSOR OF NDMA IN MALT
Author(s) -
Slack P. T.,
Wainwright T.
Publication year - 1981
Publication title -
journal of the institute of brewing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.523
H-Index - 51
eISSN - 2050-0416
pISSN - 0046-9750
DOI - 10.1002/j.2050-0416.1981.tb04028.x
Subject(s) - chemistry , nitrite , chromatography , amine gas treating , high performance liquid chromatography , gas chromatography , n nitrosodimethylamine , organic chemistry , carcinogen , nitrate
Hordenine can be nitrosated by gaseous oxides of nitrogen (NO x ) or by nitrite at acidic pH to form N‐nitrosodimethylamine (NDMA). Descending paper chromatography of an amine fraction from malt shows that a precursor of NDMA co‐chromatographs with hordenine. Measurements of hordenine in malt show that it is present at levels greatly exceeding those needed to form high levels of NDMA. A rapid method for the measurement of hordenine in malt using High Performance Liquid Chromatography (HPLC) is described.