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LH‐RH Agonists and Antagonists
Author(s) -
Schally Andrew V.,
Coy David H.,
Arimura Akira
Publication year - 1980
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1980.tb00507.x
Subject(s) - medicine , luteinizing hormone , inhibitory postsynaptic potential , hormone , pharmacology , endocrinology
Large doses of stimulatory analogues of luteinizing hormone‐releasing hormone (LH‐RH) caused paradoxical anti‐fertility effects. These effects are being utilized for the possible development of contraceptive methods. Several inhibitory analogues of LH‐RH have been tested in men and women and shown to be active. The synthetic approach based on inhibitory analogues of LH‐RH has been proven to be feasible for development of new methods of birth control. Continued research and testing along these lines may lead to the development of contraceptives based on inhibitory analogues of LH‐RH that could be conveniently applied as a nasal spray and that could be free of undesirable side effects.