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The Relative Value of Two Concentrations of Hypertonic Saline for Midtrimester Abortion
Author(s) -
Ghosh A. K.,
Konar J. R.
Publication year - 1980
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1980.tb00302.x
Subject(s) - medicine , hypertonic saline , saline , abortion , incidence (geometry) , obstetrics , pregnancy , incomplete abortion , anesthesia , misoprostol , physics , biology , optics , genetics
A study was conducted in Calcutta, India, to evaluate and compare the safety and effectiveness of the intraamniotic instillation of 5% and 20% saline in 359 women undergoing midtrimester pregnancy termination. The two abortion techniques were randomly assigned to the study patients. The incidence of method failures in the 5% (9.4%) and 20% (7.2%) saline groups was not significantly different (p < 0.05), nor was the incidence of incomplete abortion rates for the two groups significantly different (p < 0.05). At 24 hours or less, the abortion rates were significantly higher (p < 0.05) for women receiving the 20% saline, but at 36 and 48 hours there was no significant difference (p < 0.05). The mean induction‐to‐abortion interval was higher for the 5% (30.1 hours) than for the 20% (28.8 hours) saline cases, but this was not significantly significant. The incidences of excessive blood loss and fever were significantly higher (p < 0.05) for patients receiving the 5% than for those receiving the 20% saline. There were five (2.4%) deaths among the 20% and one death (0.7%) among the 5% saline groups.