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Studies of Circulation and Acid‐Base Balance in Pregnant Sheep: II. The Effect of Magnesium Sulfate Infusion
Author(s) -
Ayromlooi Jahangir,
Tobias Mitchell,
Desiderio Denise
Publication year - 1980
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1980.tb00287.x
Subject(s) - magnesium , fetus , blood pressure , medicine , gestation , anesthesia , hemoglobin , tachycardia , eclampsia , arterial blood , pregnancy , fetal circulation , pco2 , placenta , chemistry , biology , genetics , organic chemistry
Ten infusions of magnesium sulfate, in clinical doses for toxemia therapy, were administered to seven chronically catheterized ewes at 109‐126 days' gestation. Maternal and fetal Mg ++ concentrations in arterial serum indicated hindered placental passage. A significant decrease in maternal arterial oxygen pressure and hemoglobin was seen at 15 minutes. A significant increase in maternal arterial carbon dioxide pressure and transient maternal hypotension and tachycardia were seen at five minutes. Fetal effects of maternal infusion were minimal and transient. All maternal and fetal parameters returned to control levels by 90 minutes.