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Studies of Circulation and Acid‐Base Balance in Pregnant Sheep: I. The Effect of Aminophylline Infusion
Author(s) -
Ayromlooi Jahangir,
Tobias Mitchell,
Desiderio Denise
Publication year - 1980
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1980.tb00286.x
Subject(s) - medicine , aminophylline , anesthesia , blood pressure , fetus , pco2 , respiratory alkalosis , hemodynamics , gestation , blood flow , decompensation , pregnancy , metabolic acidosis , biology , genetics
The maternal and fetal effects of aminophylline on hemodynamics and acid‐base and blood gas balances were evaluated by 11 infusions to four chronically catheterized sheep at 114‐142 days' gestation. Maternal and fetal arterial blood samples were drawn for baseline determination at 15‐minute intervals. Mean maternal and fetal pH levels and heart rates increased significantly. Respiratory alkalosis was indicated by a concomitant fall in mean maternal carbon dioxide pressure. We conclude that aminophylline infusion (5.6 mg/kg of body weight/15 min) to pregnant sheep may cause maternal and fetal tachycardia and alkalosis, with a possible increase in uterine blood flow, but no changes in fetal blood gas status or blood pressure.