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TRH‐Induced Hyperprolactinemia and Pituitary‐Ovarian Function
Author(s) -
Ylikorkala Olavi,
Dawood M. Yusoff,
Kivinen Seppo
Publication year - 1980
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1980.tb00211.x
Subject(s) - prolactin , luteal phase , medicine , endocrinology , thyrotropin releasing hormone , menstrual cycle , hormone , ovary
To elucidate the role of prolactin in the control of pituitary‐ovarian function, eight healthy women were given 80 mg of synthetic thyrotropin‐releasing hormone (TRH) orally on two consecutive days during the luteal phase of their menstrual cycle. TRH elevated serum prolactin to a mean concentration of 43.8 ng/ml on the first day and to 15.5 ng/ml on the second day. The reduced response to the second TRH dose was statistically significant (p < 0.05). Accompanying changes in concentrations of gonadotropins or ovarian steroids were not consistent. Short‐term oral administration of TRH and/or the temporary hyperprolactinemia induced by its use do not modify the pituitary‐ovarian function during the luteal phase of the menstrual cycle.