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Clonidine in the Treatment of Menopausal Symptoms
Author(s) -
Salmi Tuula,
Punn Reijo
Publication year - 1979
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1979.tb00479.x
Subject(s) - clonidine , medicine , placebo , anesthesia , crossover study , incidence (geometry) , physics , alternative medicine , pathology , optics
Thirty‐seven women complaining of hot flushes, sweating and other menopausal symptoms were treated with clonidine. A double‐blind crossover trial with placebo controls was undertaken. The clonidine dose was 2 × 0.025 mg/24 hours–0.075 mg/24 hours, increased if necessary at intervals of two weeks. The effect of clonidine did not differ significantly from placebo effect in the treatment of the symptoms. Side effects during clonidine management were slight and no difference was seen in their incidence compared with that in the patients treated with the placebo. A definitive placebo response was perceivable in the decreasing of symptoms.