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A Comparative Study of the Efficiency of Hydroxyprogesterone Caproate and of Chlormadinone Acetate in the Prevention of Premature Labor
Author(s) -
Bréart Gérard,
Lanfranchi Michel,
Chavigny Charlette,
RumeauRouquette Claude,
Sureau Claude
Publication year - 1979
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1979.tb00469.x
Subject(s) - medicine , chlormadinone acetate , hydroxyprogesterone , gestation , obstetrics , premature birth , premature labor , population , gynecology , pregnancy , research methodology , hormone , environmental health , steroid , biology , genetics
The efficacy of caproate of hydroxyprogesterone and acetate of chlormadinone in preventing premature labore was compared in a controlled trial. The survey was based on 211 pregnant women with a high risk of premature delivery discovered during clinical examination. There are no significant differences between the two groups in either length of gestation, delay between the beginning of treatment and delivery or other parameters related to prematurity. The absence of evidence suggesting any significant difference between the two treatments can have three possible causes (which are discussed): the methodology, the inefficacy of the two products or the equivalent efficacy of the two products.