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Peptide Contraception: Antifertility Properties of LH‐RH Analogues
Author(s) -
Corbin Alan,
Beattie Craig W.,
Jones Robert,
Bex Frederick
Publication year - 1979
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1979.tb00466.x
Subject(s) - medicine , family planning , physiology , gynecology , endocrinology , traditional medicine , research methodology , population , environmental health
A prototype LH‐RH antagonist dampened the proestrous gonadotropin surge and blocked ovulation but had no effect on pregnant animals. In contrast, LH‐RH and two highly potent LH‐RH agonists terminated pregnancy when administrated prior to or following implantation. This contragestational effect, as well as other antireproductive properties of the agonists, coupled with the reversibility of their effects, strongly suggest that such peptides may provide a new basis for contraception.