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The Effect of Medroxyprogesterone Acetate on Blood Pressure
Author(s) -
Black Henry R.,
Leppert Phyllis,
DeCherney Alan
Publication year - 1979
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1979.tb00121.x
Subject(s) - medroxyprogesterone acetate , blood pressure , medicine , medroxyprogesterone , basal (medicine) , endocrinology , estrogen , insulin
Twenty‐four women (21 normotensive and 3 hypertensive) aged 16–35 years received 150‐mg injections of medroxyprogesterone acetate (MPA) for contraception. Their blood pressure (BP) was measured under basal conditions by the same nurse before treatment and at 1‐, 2‐ and 3‐month intervals. Their mean BP fell from 124.1/79.4 to 119.8/74.6 mm Hg at one month (p < 0.05 for diastolic pressure) to 117.0/74.9 mm Hg at two months and to 115.6/73.2 mm Hg at three months. When the normotensive patients were analyzed separately, their BP fell, but not significantly. Only one patient had a rise of 20 mm Hg systolic, but she remained normotensive. We conclude that medroxyprogesterone acetate does not raise BP.