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Midtrimester Abortion With Prostaglandin and Hypertonic Saline—A Comparative Study
Author(s) -
Bhatt R. V.,
Pachauri Saroj,
Koshy Elizabeth,
Chauhan Lalji,
Mulgaonkar Veena
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1978.tb00438.x
Subject(s) - medicine , saline , hypertonic saline , oxytocin , abortion , gestation , incomplete abortion , anesthesia , prostaglandin , obstetrics , pregnancy , misoprostol , biology , genetics
This study was conducted in Baroda, India, to evaluate and compare the safety and effectiveness of intraamniotic prostaglandin F 2α (PGF 2α ) and 20% saline augmented with intravenous oxytocin for terminating 200 pregnancies of 14 to 20 weeks' gestation. While there was no method failure among the group treated with saline, ten method failures were reported for patients treated with the PGF 2α . The rate of incomplete abortions was significantly lower for the group treated with saline (19.4%) than it was for the group treated with the PGF 2α (33.7%). The administration of oxytocin after fetal expulsion did not reduce the rate of incomplete abortion. The mean instillation‐to‐abortion time was significantly lower with saline than with PGF 2α . The incidence of gastrointestinal side effects and excessive bleeding (<200 ml) during the procedure was significantly higher for patients treated with PGF 2α than for those treated with saline.