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Histologic Malignancy Grading in Invasive Squamous Cell Carcinoma of the Vulva
Author(s) -
Kabulski Z.,
Frankman O.
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1978.tb00433.x
Subject(s) - grading (engineering) , malignancy , medicine , vulva , vulvar carcinoma , basal cell , carcinoma , pathology , retrospective cohort study , radiology , biology , ecology
A preliminary report on a histologic malignancy grading of vulvar carcinoma is presented. A retrospective histologic study of 40 vulvar carcinoma cases stage I and II (TNM‐system) with a minimum five‐year follow‐up was carried out and correlated to the course of the disease. Morphologic criteria characterizing the tumor cell population, as well as the tumor‐host relationship, were examined and scored. The scores obtained could be divided into three groups that correlated well with the clinical outcome. The low‐score group had no metastases or recurrence, whereas 82% of the high‐score group had both metastases and fatalities. Depth of invasion was found to have a strong correlation to clinical outcome. A more accurate morphologic malignancy grading of such carcinomas could lead to a more individual and often less radical treatment plan.