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Plasma Concentrations of Methylergometrine After Intravenous and Intramuscular Administration
Author(s) -
Kanto J.,
Allonen H.,
Erkkola R.,
Kleimola T.,
Mantyla R.
Publication year - 1978
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1002/j.1879-3479.1978.tb00421.x
Subject(s) - medicine , radioimmunoassay , intramuscular injection , plasma concentration , route of administration , anesthesia , pharmacology
The concentrations of methylergometrine (M) in the plasma were determined by a new radioimmunoassay after a single intravenous and intramuscular administration of two brands, Methergin (Sandoz Pharmaceuticals, Inc, East Hanover, NJ, USA) and Myomergin (Leiras Pharmaceuticals, Turku, Finland). No significant differences between the two brands were found. After the intravenous injection, M distributed quickly from the plasma to the tissues, and according to the elimination phase half‐life M has no cumulative properties. After the intramuscular injection, M was absorbed quickly with peak plasma concentrations at one‐half hour.